The most prescribed IV iron in the US

MORE THAN 25 MILLION PATIENTS TREATED GLOBALLY WITH OVER 500 MILLION UNITS.2*

Venofer® (iron sucrose injection, USP) is an established and effective treatment for chronic kidney disease (CKD) patients experiencing iron deficiency anemia.

*Patients are calculated based on an estimated annual cumulative dose. Data on file, American Regent, Inc.

Dosing & Administration

Venofer is indicated for the treatment of iron deficiency anemia in patients with CKD. Below are Venofer dosing and administration instructions for adult and pediatric patients.

Adult CKD Patients3

The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs.

Adult Patients

IV Push

100 mg over
2–5 min

  • Hemodialysis-dependent chronic kidney disease (HDD-CKD)
  • Consecutive dialysis sessions

200 mg over
2–5 min

  • Non-dialysis-dependent chronic kidney disease (NDD-CKD)
  • Five occasions over 14 days

Adult Patients

Infusion*

Diluted with 0.9% sodium chloride injection at concentrations of 1–2 mg/mL

100 mg/100 mL
over 15 min

  • Hemodialysis-dependent chronic kidney disease (HDD-CKD)
  • Consecutive dialysis sessions

200 mg/100 mL
over 15 min

  • Non-dialysis-dependent chronic kidney disease (NDD-CKD)
  • Five occasions over 14 days

2 doses of 300 mg/250 mL over 1.5 hrs
plus
1 dose of 400 mg/250 mL over 2.5 hrs

  • Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD)
  • 14 days apart

*Administer early during the dialysis session.

Pediatric CKD Patients3

Venofer treatment may be repeated if necessary. The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD), or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established.

Pediatric Patients

(2 years of age or older) with HDD-CKD

For iron maintenance treatment, administer Venofer

  • At a dose of 0.5 mg/kg, not to exceed 100 mg per dose
  • Every 2 weeks for 12 weeks
  • Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1–2 mg/mL and administered over 5–60 minutes

Pediatric Patients

(2 years of age or older) with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment

For iron maintenance treatment, administer Venofer

  • At a dose of 0.5 mg/kg, not to exceed 100 mg per dose
  • Every 4 weeks for 12 weeks
  • Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1–2 mg/mL and administered over 5–60 minutes

Venofer has not been studied in patients younger than 2 years old.

REFERENCES

1. IQVIA [NSP Audit from MAT November 2013 to November 2018]. 2. Data on file, Iron Sucrose Periodic Safety Update Report, 2018. Shirley, NY: American Regent, Inc. 3. Venofer® [package insert]. Shirley, NY: American Regent, Inc.; 2019.